How the new obesity pills could upend American society
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About a decade ago, Susan Yanovski, an obesity researcher at the National Institutes of Health, held a symposium to discuss a question that bedeviled her field: Why was it so hard to develop weight-loss drugs that actually worked and didn’t harm the people they were meant to help?
For years, the most popular weight-loss pills had earned their stigma. For example, the drug cocktail known as fen-phen was taken off the market for causing heart disease almost as reliably as it promoted healthy weight loss. The only intervention that seemed to work consistently was bariatric surgery. Doctors sliced into patients’ digestive system to reduce stomach size and slow the absorption of nutrients to stave off feelings of hunger. But these operations were expensive and complicated, and in some cases posed serious risks.