The unexpected departure puts another potentially contentious confirmation battle on the horizon.
Labor Secretary Hilda Solis announced her resignation Wednesday, creating another opening in the Cabinet reshuffle that will kick off President Obama's second term.
The departure of Solis means there's one less woman and one less minority in a White House that has recently come in for criticism for its lack of diversity. And it opens the door to another potentially contentious confirmation battle for Obama.
The president's nominees for Defense, former Senator Chuck Hagel, and Treasury, current Chief of Staff Jack Lew, have already come under fire from Republicans. Given the hot-button nature of environmental and labor issues, the candidates nominated to replace Solis and the outgoing administrator of the Environmental Protection Agency, Lisa Jackson, are also likely to face close scrutiny. (Solis's 2009 confirmation was delayed by tax issues and Republican concerns about her ties to a pro-union group.)
Combined with an upcoming welter of fiscal deadlines, the coming confirmation fights further cloud the picture for other potential policy priorities of Obama's second term, notably immigration reform and gun control.