Inoye was first elected in 1962. O'Keefe reports his last words were "Aloha." Democratic Gov. Neal Abercrombie will appoint a replacement.
On the Senate floor, Senate Majority Leader Harry Reid said, "He believed in me more than I believed in myself many, many years ago."
Below, a video of Inoye talking about winning his Medal of Honor:
And here's Inouye with President John F. Kennedy in 1963:
And here he is wearing some way cool glasses during the Watergate hearings in 1973:
And here he is with Joe DiMaggio and Muhammad Ali in 1986, when they were getting their Ellis Island Medals of Honor.
(Photos via Associated Press.)