With regard to the Middle East nuclear free zone, Kevin Drum's quite right that for the US to unilaterally propose this only to have the Israelis reject it would be counterproductive. What I believe Brzezinski was saying is that Israel would serve its own interests well by being open to the establishment of a region-wide nuclear free zone, were such a zone to be implemented in a verifiable way.

The point is that Israel would be better off with a nuclear free Middle East than with a Middle East featuring many nuclear powers and that the odds of maintaining Israel's sole possession of a nuclear arsenal are poor over the long run.