For weeks, Americans looked on as other countries grappled with case reports of rare, sometimes fatal blood abnormalities among those who had received the AstraZeneca vaccine against COVID-19. That vaccine has not yet been authorized by the FDA, so restrictions on its use throughout Europe did not get that much attention in the United States. But Americans experienced a rude awakening this week when public-health officials called for a pause on the use of the Johnson & Johnson vaccine, after a few cases of the same, unusual blood-clotting syndrome turned up among the millions of people in the country who have received it.

The world is now engaged in a vaccination program unlike anything we have seen in our lifetimes, and with it, unprecedented scrutiny of ultra-rare but dangerous side effects. An estimated 852 million COVID-19 vaccine doses have been administered across 154 countries, according to data collected by Bloomberg. Last week, the European Medicines Agency, which regulates medicines in the European Union, concluded that the unusual clotting events were indeed a side effect of the AstraZeneca vaccine; by that point, more than 220 cases of dangerous blood abnormalities had been identified. Only half a dozen cases have been documented so far among Americans vaccinated with the Johnson & Johnson vaccine, and a causal link has not yet been established. But the latest news suggests that the scope of this problem might be changing.

In 2015, in the Dallas suburb of Irving, the fates of two very different Texans collided.

One was 14-year-old Ahmed Mohamed, a precocious kid in a NASA T-shirt who had built a clock out of spare parts and brought it to school in a pencil case. His English teacher decided it might be a bomb, and the school called the police, who arrested Mohamed for bringing in a “hoax bomb.” Because Mohamed’s family was part of Irving’s large Muslim minority, many liberals saw this as a baseless case of Islamophobia.

The other Texan was Irving Mayor Beth Van Duyne, a blond 44-year-old with Disney-princess bone structure. She defended Mohamed’s arrest on Facebook, then went on The Glenn Beck Program to repeat the “hoax bomb” lie and complain that the child hadn’t given police enough information. “We’ve heard more from the media than the child ever released to the police when we were asking him questions,” she said calmly.

A year ago, when the United States decided to go big on vaccines, it bet on nearly every horse, investing in a spectrum of technologies. The safest bets, in a way, repurposed the technology behind existing vaccines, such as protein-based ones for tetanus or hepatitis B. The medium bets were on vaccines made by Johnson & Johnson and AstraZeneca, which use adenovirus vectors, a technology that had been tested before but not deployed on a large scale. The long shots were based on the use of mRNA, the newest and most unproven technology.

The protein-based vaccines have moved too slowly to matter so far. J&J’s and AstraZeneca’s vaccines are effective at preventing COVID-19—but a small number of recipients have developed a rare type of blood clot that appears to be linked to the adenovirus technology and may ultimately limit those shots’ use. Meanwhile, with more than 180 million doses administered in the U.S, the mRNA vaccines have proved astonishingly effective and extremely safe. The unusual blood clots have not appeared with Pfizer’s or Moderna’s mRNA technology. A year later, the risky bet definitely looks like a good one.

The president was insistent as he left office: “We’re not going anywhere.” It had been a turbulent end of the presidency—impeachment, appalling pardons, and a lengthy dispute over the outcome of the presidential election—but he knew that he had a devoted following, and he had every intention to remain a force in politics. And not just him: His family was eager to cash in on his electoral success, too. Usually a former president laid low for a while after leaving office. He wasn’t going to do that. He’d remain a political force, and the dominant figure in his party.

But the plan didn’t go well. The president sat at his new home—he had decamped from his longtime home state—guzzling Diet Cokes and calling friends to rage about how unfairly he’d been treated and complain about overzealous prosecutors. “You get tired of listening to it,” one friend confessed.

Last week, the CDC acknowledged what many of us have been saying for almost nine months about cleaning surfaces to prevent transmission by touch of the coronavirus: It’s pure hygiene theater.

“Based on available epidemiological data and studies of environmental transmission factors,” the CDC concluded, “surface transmission is not the main route by which SARS-CoV-2 spreads, and the risk is considered to be low.” In other words: You can put away the bleach, cancel your recurring Amazon subscription for disinfectant wipes, and stop punishing every square inch of classroom floor, restaurant table, and train seat with high-tech antimicrobial blasts. COVID-19 is airborne: It spreads through tiny aerosolized droplets that linger in the air in unventilated spaces. Touching stuff just doesn’t carry much risk, and more people should say so, very loudly.

Illustrations by Leonardo Santamaria

This article was published online on April 15, 2021.

The Motel El Encanto in Hermosillo, Mexico, served a lavish breakfast that John and Andra Patterson liked to eat on the tiled deck near their suite. The couple would discuss the day ahead over fresh pineapple and pan dulces while their 4-year-old daughter, Julia, watched the gray cat that skulked about the motel’s Spanish arches.

On the morning of March 22, 1974, the Pattersons’ breakfast chatter centered on their search for a permanent home. They were nearing their two-month anniversary of living in Hermosillo, where John was a junior diplomat at the American consulate, and the motel was feeling cramped.

After breakfast, Andra dropped John off at work. Because this was his first posting as a member of the United States Foreign Service, the 31-year-old Patterson had been given an unglamorous job: He was a vice consul responsible for promoting trade between the U.S. and Mexico, which on this particular Friday meant driving out to meet with a group of ranchers who hoped to improve their yield of beef.

In early March 2020, Rick Phillips, 63, and his wife, Sheryl Phillips, quietly cloistered themselves in their Indianapolis home. They swore off markets, movie theaters, the gym, and, hardest of all, visits with their three young grandchildren. This April, three weeks after receiving her second shot of Pfizer’s vaccine, Sheryl broke her social fast and walked into a grocery store for the first time since last spring. Rick has yet to join her. He received his shots on the same days his wife received hers. By official standards, he, too, can count himself as fully vaccinated. But he feels that he cannot act as though he is. “I personally remain scared to death,” he told me.

Rick has rheumatoid arthritis, which once rendered him “barely able to walk across the room,” he said. He now treats the condition with an intensely immunosuppressive drug that strips his body of the ability to churn out disease-fighting antibodies. Rick credits the treatment with changing his life. But it might also keep him from developing lasting defenses against COVID-19.

Dear Therapist,

About 10 months ago, my young adult son returned home, appearing distraught over a broken relationship. Before this, he had moved back to his university city to be with his girlfriend, who was entering her final year, and he spent four months trying to get a job and develop social networks, and being committed to the relationship.

It appears he was unsuccessful on all fronts, and my previously sunny, gregarious kid slumped into a mood matching the cold, dark winter weather in which he was living. He returned to sunny California just prior to Christmas, but struggled with sadness, anxiety, and generally feeling lost. It was clear to me that the issue was not simply a breakup and he should have come home much sooner. My other two sons returned home for the holidays, and we tried to make the best of a difficult situation. My other sons are several years older, one is married, and both live far away and are established in their careers.

“How to Build a Life” is a weekly column by Arthur Brooks, tackling questions of meaning and happiness.

Arthur C. Brooks will discuss the science of happiness live at 11 a.m. ET on May 20. Register for In Pursuit of Happiness here.

In 2010, two Nobel laureates in economics published a paper that created a tidal wave of interest both inside and outside academia. With careful data analysis, the researchers showed that people believe the quality of their lives will increase as they earn more, and their feelings do improve with additional money at low income levels. But the well-being they experience flattens out at around $75,000 in annual income (about $92,000 in today’s dollars). The news materially affected people’s lives—especially the part about happiness rising up to about $75,000: In the most high-profile example, the CEO of a Seattle-based credit-card-payment company raised his employees’ minimum salary to $70,000 (and lowered his own salary to that level) after reading the paper.

Cherry blossoms in Germany, Fashion Week in Madrid, an island castle in Switzerland, Ramadan prayers in Mecca, a volcanic eruption in the Caribbean, a protest march in Minnesota, a “Field of Light” in California, a comfort dog at the U.S. Capitol, and much more