Three months ago, no one knew that SARS-CoV-2 existed. Now the virus has spread to almost every country, infecting at least 446,000 people whom we know about, and many more whom we do not. It has crashed economies and broken health-care systems, filled hospitals and emptied public spaces. It has separated people from their workplaces and their friends. It has disrupted modern society on a scale that most living people have never witnessed. Soon, most everyone in the United States will know someone who has been infected. Like World War II or the 9/11 attacks, this pandemic has already imprinted itself upon the nation’s psyche.

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A global pandemic of this scale was inevitable. In recent years, hundreds of health experts have written books, white papers, and op-eds warning of the possibility. Bill Gates has been telling anyone who would listen, including the 18 million viewers of his TED Talk. In 2018, I wrote a story for The Atlantic arguing that America was not ready for the pandemic that would eventually come. In October, the Johns Hopkins Center for Health Security war-gamed what might happen if a new coronavirus swept the globe. And then one did. Hypotheticals became reality. “What if?” became “Now what?”

Updated at 9:20 p.m. ET on April 1, 2020.

As the coronavirus pandemic continues, many people are now overthinking things they never used to think about at all. Can you go outside? What if you’re walking downwind of another person? What if you’re stuck waiting at a crosswalk and someone is there? What if you’re going for a run, and another runner is heading toward you, and the sidewalk is narrow? Suddenly, daily mundanities seem to demand strategy.

Much of this confusion stems from the shifting conversation around the pandemic. Thus far, the official line has been that the new coronavirus, SARS-CoV-2, could be transmitted only through close contact with infected people or contaminated surfaces. But recently, news reports have suggested that the coronavirus can spread through the air. After 60 choir members in Washington State rehearsed together, 45 fell sick, even though no one seemed symptomatic at the time. Now people who were already feeling cooped up are worrying about going outside. Many state guidelines are ambiguous, and medical advice can muddy matters further. When the writer Deborah Copaken came down with COVID-19 symptoms, her doctor chided her for riding her bike through New York City a week earlier. Going outside in the city wasn’t safe, the physician implied, with “viral load everywhere.”

From inside her living room in London, Paula Koelemeijer can feel the world around her growing quieter.

Koelemeijer, a seismologist, has a miniature seismometer sitting on a concrete slab at the base of her first-floor fireplace. The apparatus, though smaller than a box of tissues, can sense all kinds of movement, from the rattle of trains on the tracks near Koelemeijer’s home to the waves of earthquakes rolling in from afar. Since the United Kingdom announced stricter social-distancing rules last month, telling residents not to leave their home except for essential reasons, the seismometer has registered a sharp decrease in the vibrations produced by human activity.

With fewer trains, buses, and people pounding the pavement, the usual hum of public life has vanished, and so has its dependable rhythms: Before the spread of COVID-19 shut down the city, Koelemeijer could plot the seismometer’s data and see the train schedule reflected in the spikes, down to the minute. Now, with fewer trains running, the spikes seem to come at random.

The Trump administration has just released the model for the trajectory of the COVID-19 pandemic in America. We can expect a lot of back-and-forth about whether its mortality estimates are too high or low. And its wide range of possible outcomes is certainly confusing: What’s the right number? The answer is both difficult and simple. Here’s the difficult part: There is no right answer. But here’s the simple part: Right answers are not what epidemiological models are for.

Epidemiologists routinely turn to models to predict the progression of an infectious disease. Fighting public suspicion of these models is as old as modern epidemiology, which traces its origins back to John Snow’s famous cholera maps in 1854. Those maps proved, for the first time, that London’s terrible affliction was spreading through crystal-clear fresh water that came out of pumps, not the city’s foul-smelling air. Many people didn’t believe Snow, because they lived in a world without a clear understanding of germ theory and only the most rudimentary microscopes.

In a matter of weeks, the coronavirus has gone from a novel, distant threat to an enemy besieging cities and towns across the world. The burden of COVID-19 and the economic upheaval wrought by the measures to contain it feel epochal. Humanity now has a common foe, and we will grow increasingly familiar with its face.

Yet plenty of this virus’s aspects remain unknown. The developing wisdom—earned the hard way in Wuhan, Washington, and Italy—has been that older people and sicker people are substantially more likely to suffer severe illness or die from COVID-19 than their younger, healthier counterparts. Older people are much more likely than young people to have lung disease, kidney disease, hypertension, or heart disease, and those conditions are more likely to transform a coronavirus infection into something nastier. But what happens when these assumptions don’t hold up, and the young people battling the pandemic share the same risks?

Updated at 4:40 ET on March 30, 2020.

The new coronavirus has brought American life to a near standstill, closing businesses, canceling large gatherings, and keeping people at home. All of those people must surely be wondering: When will things return to normal?

The answer is simple, if not exactly satisfying: when enough of the population—possibly 60 or 80 percent of people—is resistant to COVID-19 to stifle the disease’s spread from person to person. That is the end goal, although no one knows exactly how long it will take to get there.

There are two realistic paths to achieving this “population-level immunity.” One is the development of a vaccine. The other is for the disease to work its way through the population, surely killing many, but also leaving many others—those who contract the disease and then recover—immune. “They’re just Teflon at that point,” meaning they can’t get infected again and they won’t pass on the disease, explains Andrew Noymer, a public-health professor at UC Irvine. Once enough people reach Teflon status—though we don’t yet know if recovering from the disease confers any immunity at all, let alone lifelong immunity—normalcy will be restored. (It may also turn out to be the case that people who are immune to the disease can still pass it on under certain circumstances.)*

For the second straight week, the U.S. workforce set a dismal unemployment record. On Thursday morning, the Labor Department reported that 6.6 million people filed new claims for unemployment benefits last week. That figure is twice as high as the previous record of 3.3 million, set just seven days ago.

This brings the two-week total of initial claims to nearly 10 million. That’s 10 million Americans who have lost their jobs—and, in many cases, their health insurance—in the spiraling chaos of a public-health crisis. Ten million Americans who have been thrust into unemployment-insurance programs, with their company on pause, their start-up ruined, or their business closed, and no clear timeline for reopening. Ten million Americans, many effectively quarantined by local law, simultaneously dealing with sudden confinement and sudden joblessness, separated from their daily habits and prohibited from leaving their apartment to commiserate with colleagues, or seek comfort in the arms of family.

Enough already. When people try to be cheerful about social distancing and working from home, noting that William Shakespeare and Isaac Newton did some of their best work while England was ravaged by the plague, there is an obvious response: Neither of them had child-care responsibilities.

Shakespeare spent most of his career in London, where the theaters were, while his family lived in Stratford-upon-Avon. During the plague of 1606, the playwright was lucky to be spared from the epidemic—his landlady died at the height of the outbreak—and his wife and two adult daughters stayed safely in the Warwickshire countryside. Newton, meanwhile, never married or had children. He saw out the Great Plague of 1665–6 on his family’s estate in the east of England, and spent most of his adult life as a fellow at Cambridge University, where his meals and housekeeping were provided by the college.

“WE CANNOT LET THE CURE BE WORSE THAN THE PROBLEM ITSELF.”

With this tweet, President Donald Trump summarized a disturbingly common reaction to social-distancing measures. Texas Lieutenant Governor Dan Patrick expressed the same sentiment when he told Americans to “get back to work,” even if doing so means more death. Fox News commentators, likewise, have argued that Americans should break free of the shackles of quarantine to reboot the economy.

Call it the gospel of growth: the notion that Americans cannot afford to save tens of thousands, even hundreds of thousands, of lives, if it means sacrificing a quarter or two of gross domestic product.

Read: Reopening the economy is pointless when cities are under siege

For his entire adult life, and for his entire presidency, Donald Trump has created his own alternate reality, complete with his own alternate set of facts. He has shown himself to be erratic, impulsive, narcissistic, vindictive, cruel, mendacious, and devoid of empathy. None of that is new.

But we’re now entering the most dangerous phase of the Trump presidency. The pain and hardship that the United States is only beginning to experience stem from a crisis that the president is utterly unsuited to deal with, either intellectually or temperamentally. When things were going relatively well, the nation could more easily absorb the costs of Trump’s psychological and moral distortions and disfigurements. But those days are behind us. The coronavirus pandemic has created the conditions that can catalyze a destructive set of responses from an individual with Trump’s characterological defects and disordered personality.