february 2001

Two and a half years and billions of estimated infections into this pandemic, SARS-CoV-2’s visit has clearly turned into a permanent stay. Experts knew from early on that, for almost everyone, infection with this coronavirus would be inevitable. As James Hamblin memorably put it back in February 2020, “You’re Likely to Get the Coronavirus.” By this point, in fact, most Americans have. But now, as wave after wave continues to pummel the globe, a grimmer reality is playing out. You’re not just likely to get the coronavirus. You’re likely to get it again and again and again.

“I personally know several individuals who have had COVID in almost every wave,” says Salim Abdool Karim, a clinical infectious-diseases epidemiologist and the director of the Center for the AIDS Program of Research in South Africa, which has experienced five meticulously tracked surges, and where just one-third of the population is vaccinated. Experts doubt that clip of reinfection—several times a year—will continue over the long term, given the continued ratcheting up of immunity and potential slowdown of variant emergence. But a more sluggish rate would still lead to lots of comeback cases. Aubree Gordon, an epidemiologist at the University of Michigan, told me that her best guess for the future has the virus infiltrating each of us, on average, every three years or so. “Barring some intervention that really changes the landscape,” she said, “we will all get SARS-CoV-2 multiple times in our life.”

The first data on Paxlovid, out last November, hinted that the COVID antiviral would cut the risk of hospitalization and death by 89 percent. Pundits called the drug “a monster breakthrough,” “miraculous,” and “the biggest advance in the pandemic since the vaccines.” “Today’s news is a real game-changer,” said Albert Bourla, the CEO of Pfizer, which makes the drug. The pills are “a game changer,” President Joe Biden repeated a few months later.

Now, finally, the game is being changed. The government has ordered 20 million courses of Paxlovid, committing half of the $10 billion in additional COVID funding that is being negotiated in the Senate; and Pfizer says that the number of patients taking the drug increased by a factor of 10 between mid-February and late April.

“How to Build a Life” is a weekly column by Arthur Brooks, tackling questions of meaning and happiness. Click here to listen to his podcast series on all things happiness, How to Build a Happy Life.

The dirty secret of social scientists is that a lot of research is actually “me-search.” Many of us tend to study aspects of life that affect us personally, looking for solutions to our own issues. In that spirit, I celebrated my 58th birthday last week not with a toupee or red sports car, but rather by investigating how to have the best possible midlife crisis.

The midlife-crisis phenomenon has taken on almost mythic proportions in the American psyche over the past century. The term was first coined by the Canadian psychoanalyst Elliott Jaques, who noticed a pattern in the lives of “great men” in history: Many of them lost productivity—and even died—in their mid-to-late-30s, which was midlife in past centuries. The idea entered the popular consciousness in the 1970s when the author Gail Sheehy wrote her mega–best seller Passages: Predictable Crises of Adult Life. Sheehy argued that around the age of 40, both men and women tend to descend into a crisis about getting old, running out of time to meet their goals, and questioning life choices. She based her work on in-depth case interviews with 115 individuals, the most famous of whom was the auto entrepreneur John DeLorean. He went on to become infamous in 1982, when, at the age of 57, he was arrested for attempting to sell about 60 pounds of cocaine to undercover federal agents.

The grieving people of Uvalde, Texas, a town in the Hill Country about 80 miles west of San Antonio, now confront the irreplaceability of life in one of its most ghastly and unnatural incarnations: the murder of at least 19 children and two adults, with several more injured. In their mourning they will join dozens of other communities scattered throughout the country where school shootings this year alone have injured or killed people, and in their special torture—these children were elementary schoolers; they still had the faintly round faces of babies—they will join the families of the children murdered at Sandy Hook Elementary School in another episode of stochastic annihilation only 10 years ago.

My advice, if you are in an active-shooter situation, is the same no matter your age. Listen for the source of the shooting. Give yourself at most two seconds for this task. Those are not firecrackers. Then run as fast as you can in the other direction, and do not stop running until the only thing you hear is the sound of birds chirping, wind in the trees or grass, and the beating of your own heart. My advice differs only if you are responsible for others on the scene—in which case you need to get those other people to run away with you—or if you are an armed guard or cop, in which case you should run, too, but not away.

Videos emerging from Robb Elementary School, in Uvalde, Texas, appear to show parents urging police to storm the school and free their children, who were inside the school with the killer. Their requests were, at the moment of the video, denied—even though these cops are well armed and not apparently engaged in any activity more strenuous than waiting in the parking lot. According to The Wall Street Journal, the police pepper-sprayed a dad outside the school and handcuffed a distraught mom when she tried to enter. She had driven 40 miles to get to the school. When they uncuffed her, she “jumped the school fence, and ran inside to grab her two children. She sprinted out of the school with them.”