A chemist once at the center of an era-defining sports scandal now is eager to improve your health.
After 30 minutes, the rat should have been dead. Sealed in a capsule-shaped chamber, the animal was breathing pure oxygen at a pressure high enough to cause a normal rat to have a seizure in five to 10 minutes. Dominic D’Agostino, a researcher at the University of South Florida, stood by, ready to flush the chamber with fresh air and rescue the creature at the first signs of a problem. But 30 minutes became 40 minutes, and still the rat appeared unbothered. At an hour, D’Agostino could only gaze at it on a video monitor with wonder. “The rat was just kind of staring back at us and grooming itself,” he says.
Shortly before placing the rat inside the chamber, D’Agostino had injected a new, one-of-a-kind molecule down the animal’s throat. Much of D’Agostino’s work is funded by the U.S. Department of Defense’s Office of Naval Research, and this experiment, which he conducted in mid-2011, was his first test of whether the new molecule could help a rat withstand an onslaught of oxygen. The hope was to one day do the same for Navy divers, who can experience devastating oxygen-toxicity seizures on deep dives.