A new study find some biological differences in the brains of people suffering fro chronic fatigue syndrome, but little that can explain the problem.

Chronic Fatigue Syndrome (CFS) has remained a mystery for a long time, and in some ways it's only deepening. It was once believed that the syndrome was caused by a virus - but this theory was recently discredited, leaving researchers to search for a new explanation.
Some are now interested in understanding the brains of people with CFS, and hoping to find some answers there. A new study has reported that there are some fundamental differences between people with and without CFS. Whether the findings will truly uncover more answers is still unclear.
the team found that people with CFS had less change in blood flow between winning and losing. What's more, people with more severe CFS had even less change in blood flow.
The team had noticed that people who were treated with interferon for Hepatitis C often experienced extreme fatigue as a result. They also had less activity in an area of the brain called the basal ganglia, which is responsible for the perception of pleasure, and often referred to as the brain's "reward center." So they reasoned that similar brain changes might be going on in people with CFS, for whom fatigue is ever-present and pleasure is often elusive.