Researchers at NYU have made a key step in developing a treatment for Creutzfeldt-Jakob and a host of other brain-wasting diseases
There are currently no treatments for prion diseases, brain-wasting diseases that are invariably fatal. The most common human prion disease is Creutzfeldt-Jakob disease (CJD), better known as mad cow disease.
Blood Transfusions Spread Parasite
Omega-3s: Not So Heart-Healthy?
Contraceptives Double Risk of HIV
Researchers at NYU School of Medicine recently took a key step in developing an effective treatment. They found four compounds that significantly delayed disease onset in mice. Because prion diseases are extremely slow to develop, any treatment that delays their initial symptoms long enough could potentially be life saving. And two of these anti-prion compounds are drugs already used to treat other conditions in humans, meaning that clinical trials of them may soon be underway.
The two drugs are trimipramine, an antidepressant, and fluphenazine, an antipsychotic.
Prion diseases destroy brain tissue. Collectively they're known as spongiform encephalopathies because the holes in a disease-riddled brain give it a sponge-like appearance. Animal diseases include bovine spongiform encephalopathy (BSE), commonly known as mad cow disease, scrapie and chronic wasting disease. BSE can be transmitted to humans -- over 200 people are known to have died from it, presumably from eating contaminated meat.
Prions are misfolded proteins that can produce infection and disease by eventually causing normal proteins to also misfold. Over time, once enough misfolded proteins accumulate, brain degeneration occurs. The incubation time (from infection to disease symptom appearance) is very long, anywhere from several months to decades.
While little is currently known about treating prion diseases, they may ultimately prove simpler to treat than bacterial infections. To cure a bacterial infection, all the bacteria must be killed. To effectively treat a prion disease, it may be enough to simply slow down the rate of prion growth, turning what's already a long process into a longer one that will not produce disease in a person's lifetime. The current study results are a step in that direction.
The researchers tested 68 related compounds known as styryl-based compounds, as well as trimipramine and fluphenazine, for their ability to prevent prion infections in mouse cell cultures and for toxicity. Both drugs and two of the styryl compounds, numbers 231 and 59, showed good effectiveness and were non-toxic. The researchers then tested these four compounds in mice that had been experimentally infected with prions.
Infected mice treated with any of the four compounds took 20-25 percent longer before displaying disease symptoms, with compound 231 giving the best results. And one mouse treated with trimipramine survived for the entire 400-day study, showing no disease symptoms or prion accumulation in the brain.
For ethical reasons, any mice showing disease symptoms were sacrificed three weeks after the symptoms first appeared. So the study couldn't tell much about how the four compounds slowed disease progression, only that they were somewhat effective at delaying the onset of disease symptoms. Autopsy did show that the brain tissue of treated mice had less degeneration than those of the untreated mice, presumably meaning that these compounds did slow disease progression.
The researchers hope that tests of trimipramine and fluphenazine in people with CJD will begin soon.
An article on the study was published by PLoS ONE and is freely available. To see it, click here.
Image: REUTERS/Lee Jae Won.
This article originally appeared on TheDoctorWillSeeYouNow.com.
We want to hear what you think about this article. Submit a letter to the editor or write to firstname.lastname@example.org.