A Human Brain Of Ones and Zeros?

Timothy B Lee dashes the hopes of transhumanists everywhere when he writes that we'll never be able to "emulate the human brain on a digital computer":

[Robin] Hanson’s fundamental mistake is to treat the brain like a human-designed system we could conceivably reverse-engineer rather than a natural system we can only simulate. We may have relatively good models for the operation of nerves, but these models are simplifications, and therefore they will differ in subtle ways from the operation of actual nerves. And these subtle micro-level inaccuracies will snowball into large-scale errors when we try to simulate an entire brain, in precisely the same way that small micro-level imperfections in weather models accumulate to make accurate long-range forecasting inaccurate.