Robin Handson insists that digital brains are possible:
Human brains were not designed by humans, but they were designed. Evolution has imposed huge selection pressures on brains over millions of years, to perform very particular functions. Yes, humans use more math that does natural selection to assist them. But we should expect brain emulation to be feasible because brains function to process signals, and the decoupling of signal dimensions from other system dimensions is central to achieving the function of a signal processor. The weather is not a designed signal processor, so it does not achieve such decoupling.