David Sosa argues against life inside the matrix:
There’s an important difference between having a friend and having the experience of having a friend. There’s an important difference between writing a great novel and having the experience of writing a great novel. On the machine, we would not parent children, share our love with a partner, laugh with friends (or even smile at a stranger), dance, dunk, run a marathon, quit smoking, or lose 10 pounds in time for summer. Plugged in, we would have the sorts of experience that people who actually achieve or accomplish those things have, but they would all be, in a way, false an intellectual mirage.
James Poulos expands on that point.