Pivoting off the above video of Seth Berkley talking about vaccines, TED interviews him about the never-ending search for an HIV vaccine:
On the HIV side, it’s an extraordinarily exciting time. We’re really experiencing a Renaissance in AIDS vaccine development. At the time of the TEDTalk, I discussed this retro-vaccinology concept and the host of new antibodies that have been found. Since that time there have been three more found, some of which target different areas, and we now know that if you combine a couple of them, at least in the laboratory, you can neutralize all of the strains. And so there’s a real move now to both try to understand where these antibodies are binding better and how we can make proteins to make antibodies like this, as well as whether we give these antibodies passively or do gene transfers. We could go ahead and transfer the genes that make these antibodies and so have people make them, just until we figure out exactly what the vaccine looks like. And, even while that work is going on, there is the other piece I’d mentioned, which is that there are now a lot of vaccine candidates that look far better than the first candidate that had been tested in the past and didn’t succeed. In the pipeline, there are a number of candidates that look much better in the best of the animal models, and those are working their way towards humans now.
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