Manzi has a series of responses (one, two, three) to Krugman's big climate article from a couple weeks back. Manzi's strongest argument, in his third post, rests on the other challenges we face:

In the face of massive uncertainty, hedging your bets and keeping your options open is almost always the right strategy. Money and technology are the raw materials for options to deal with physical dangers. A healthy society is constantly scanning the horizon for threats and developing contingency plans to meet them, but the loss of economic and technological development that would be required to eliminate all theorized climate change risk (or all risk from genetic and computational technologies or, for that matter, all risk from killer asteroids) would cripple our ability to deal with virtually every other foreseeable and unforeseeable risk, not to mention our ability to lead productive and interesting lives in the meantime.

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