The formula goes something like this:
Step 1--Begin by describing a philosophical challenge with a mixture of anger and fatigue, much as you would describe discovering a termite in your house after the exterminator had been through and presumably destroyed them all. The contempt must ooze front and center before you even address the argument so that anyone who might be inclined to take the challenge seriously is forewarned and suitably cowed. Don't skimp on the insulting adjectives.
Step 2--Deflect the issue from the profoundly philosophical to the mundane by suddenly talking lab gobbledegook about genes, mutations, etc.
Use words like phenotype liberally and try to throw in a diagram. Extra points for insisting Darwin himself was well aware of what you are saying and would have agreed with you unreservedly;
Step 3--Insist that any argument that comes within a hundred miles of religion, no matter how ethereal or tentative, leads directly to biblical literalism, preferably as practiced in the American South. Show in one paragraph how it is the root of every atrocity in history, will lead to the end of scientific inquiry and justifies the bombing of innocent villagers by the U.S. Air Force.
Step 4--Bask in the glow of hundreds of one-sentence comments thanking you profusely for your courage and agreeing you have proven there is no need to read what your opponent said to know that the stupid twit isn't even worth reading.