...it’s very difficult to skeptically review the scientific literature and conclude that the consensus is wrong. That’s why folks like Jim Manzi (and Ronald Bailey, who has revised his views somewhat since writing the book Taylor cites) are reluctant to confidently endorse the views in that Cato ad. But rather than accept, as an institution, that the science is probably correct and go about its business arguing that no state action is required (or whatever policy it might decide upon) Cato chose to betray the principles of honest skepticism that no doubt attracted many of libertarianism’s better minds. They’re sure to notice this choice. Hence, crisis.
Manzi's final thoughts here.