Exploring the Effects of Diet on Diabetes in Mice

This episode of the Science Bytes documentary series, produced by Kikim Media for PBS and the Public Library of Science, talks to Dr. Charles Mobbs about his research, which reversed the progress of kidney disease in mice with diabetes. Why do the mice in the diagram below appear to be eating bacon? The secret to their improved health was a low-carb (ketogenic) diet. 

Mobbs summarizes his research in a statement on the Science Bytes site:

Diabetic complications, including kidney failure, develop progressively and become apparently irreversible, even with complete correction of blood glucose. However, based on our studies of the basic mechanisms driving diabetic complications, we hypothesized that decreasing glucose metabolism as well as blood glucose levels would allow reversal of diabetic complications. We had previously shown that a particular chemical known as a ketone, which is used as fuel for the brain during nutritional deprivation, could block glucose metabolism. Ketone levels in the blood can also be produced by the low-carbohydrate low-protein ketogenic diet, which is used to treat epilepsy in people.

For more videos from Kikim Media, visit http://www.kikim.com.

Kasia Cieplak-Mayr von Baldegg is the executive producer for video at The AtlanticMore

Cieplak-Mayr von Baldegg joined The Atlantic in 2011 to launch its video channel and, in 2013, create its in-house video production department. She leads the development and production of original documentaries, interviews, and other video content for The Atlantic. Previously, she worked as a producer at Al Gore’s Current TV and as a content strategist and documentary producer in San Francisco. She studied filmmaking and digital media at Harvard University.

Our Incredible, Microscopic World

Highlights from Nikon's Small World in Motion competition, featuring zebrafish embryos, killer T cells attacking cancer, and much more

Join the Discussion

After you comment, click Post. If you’re not already logged in you will be asked to log in or register with Disqus.

Please note that The Atlantic's account system is separate from our commenting system. To log in or register with The Atlantic, use the Sign In button at the top of every page.

blog comments powered by Disqus

Video

The Horrors of Rat Hole Mining

"The river was our source of water. Now, the people won't touch it."

Video

What's Your Favorite Slang Word?

From "swag" to "on fleek," tweens choose.

Video

Cryotherapy's Dubious Appeal

James Hamblin tries a questionable medical treatment.

Video

Confessions of Moms Around the World

In Europe, mothers get maternity leave, discounted daycare, and flexible working hours.

Video

How Do Trees Know When It's Spring?

The science behind beautiful seasonal blooming

More in Video

Just In