Mutated Manuscripts: The Evolution of Genes and Texts

Mutations.jpg

Recently, Christian G. Sprecht, a neurobiologist, wrote an intriguing piece in The Scientist about how scientific citations -- references by one paper to previous ones -- mutate over time. What Sprecht meant by this is that over time, a popular paper, instead of being read and cited directly, gets cited by looking at other citations. This somewhat lazy approach is unfortunately all too common, and if a scientist types it wrong, then suddenly there is a mutated version out there, that other scientists reference, leading to a proliferation of errors. By studying these mutations you can learn about the history of the article that is being cited.

But, of course, such errors are not confined to modern scientific articles. People having been miscopying text for thousands of years. And understanding the errors in these manuscripts is actually quite similar to understanding genetics. This sounds a bit odd. What do handwritten manuscripts, from the medieval period or earlier, have to do with genetics? On the surface, nothing: one is a hard experimental science and the other is a distinguished part of the humanities. However, while those who study each of these fields have very little to do with each other, it turns out that there is a great deal of symmetry. And it mainly comes down to mutation. Scholars who study paleography - the field of research that examines ancient writing - are all-too-well-aware of the mistakes that scribes make when copying a text. These types of errors, which can be used to understand the provenance of a history of a document, are actually nearly identical to the types of errors caused by polymerase enzymes, the proteins responsible for copying DNA strands.

It's clear what a mutation is in genetics: a strand of DNA gets hit by a cosmic ray, or copied incorrectly, and some error gets introduced into the sequence. For example, an 'A' gets turned into a 'G', although they can be much larger in effect. These errors can range from causing no problem whatsoever (don't worry - the majority are like this), to causing large-scale issues due to the change in a single letter of DNA, such as in the case of sickle-cell anemia.

Well, there are also systematic errors in copying a text. Whether it's skipping a word or duplicating it, there is order to the ways in which a scribe's mind wanders during his transcription. Many of the errors can be grouped into categories of error, just like the different types of genetic mutations. And not only are there regularities to how both DNA and ancient manuscripts are copied, but it gets even better: despite the differences in terms, these types of errors are often identical.

For example, there is a scribal error known by the Greek term homeoteleuton. This refers to a type of deletion, where there are two similarly ending passages and the scribe skips to the second ending without transcribing the first intervening portion. For example, if a section read, "And you should do the following things because I am the Lord. Here's what you should do, because I am the Lord. Amen." and it was instead copied as "And you should do the following things because I am the Lord. Amen." that would be a homeoteleuton.

Presented by

Samuel Arbesman is an applied mathematician and network scientist. He is a senior scholar at the Kauffman Foundation and a fellow at the Institute for Quantitative Social Science at HarvardUniversity. His writing has appeared in The New York TimesThe AtlanticWiredNew Scientist, and The Boston Globe. He lives in Kansas City with his wife.

Google Street View, Transformed Into a Tiny Planet

A 360-degree tour of our world, made entirely from Google's panoramas

Join the Discussion

After you comment, click Post. If you’re not already logged in you will be asked to log in or register.

blog comments powered by Disqus

Video

Google Street View, Transformed Into a Tiny Planet

A 360-degree tour of our world, made entirely from Google's panoramas

Video

The 86-Year-Old Farmer Who Won't Quit

A filmmaker returns to his hometown to profile the patriarch of a family farm

Video

Riding Unicycles in a Cave

"If you fall down and break your leg, there's no way out."

Video

Carrot: A Pitch-Perfect Satire of Tech

"It's not just a vegetable. It's what a vegetable should be."

Video

The Benefits of Living Alone on a Mountain

"You really have to love solitary time by yourself."

More in Technology

Just In