Overactive Bladder? Botox Can Help

Researchers have learned the common cosmetic treatment comes with some additional benefits.

The Doctor Will See You Now
vhpfoto/Shutterstock

Botox isn't just for wrinkles any more. It can also help women with urinary incontinence lead a more normal life.

The largest study to date has found botulinum toxin (Botox) effective at calming the overactive bladders of women with urinary incontinence that had not responded to standard treatments. One Botox treatment was good for six months.

Standard treatments include pelvic floor muscle exercises to improve muscle control and anticholinergic medication, which may lower the activity of nerves that cause the bladder muscle to contract.

Nearly one-third of the women who received Botox had full control over their urination six months after treatment.

The treatment can have side effects. One of six women in the study reported difficulty urinating at some point during the six months. And urinary infections also rose in women who received Botox. But the treatment helped far more women than it caused these problems for.

A common cause of urinary incontinence is an overactive bladder muscle whose contraction isn't fully under a person's control. Standard treatments include pelvic floor muscle exercises to improve muscle control and anticholinergic medication, which may lower the activity of nerves that cause the bladder muscle to contract. While these treatments do help many sufferers, they don't help everyone. And the medication can cause side effects including constipation, dry mouth and blurred vision.

The women in the study all had severe muscle-related bladder problems that had not improved after eight weeks of conventional treatment.

Over four years, the RELAX study recruited 240 such women from eight UK hospitals. A total of 122 received injections of 200 International Units (IU) of botulinum toxin, 20 IU each at 10 different sites in the bladder wall, while 118 received 10 injections of saline. The women reported on how the treatment was working six weeks, three months and six months after treatment.

Thirty-one percent of the women who received Botox reported being fully continent six months afterward, compared to 12 percent who received saline injections. And even those who did not become fully continent reported benefits: on average, leakage episodes decreased from 6.0 to 1.67 per day.

The most common side effects were urinary tract infection and difficulty urinating. Urinary tract infection occurred in three times as many women who received Botox as in those who received saline (36 women to 12). And four times as many women who received Botox had enough difficulty urinating to require occasional self-catheterization, (16 women to four).

It's possible that these side effects can be reduced by altering the initial dosage of Botox; this is a fairly new procedure.

Self-catheterization requires learning how to insert a plastic or rubber tube into the urethra to collect the urine, a procedure which can be inconvenient. But most of the women in the study who had to resort to it found it preferable to their pre-study state of affairs. And those who had no such need were delighted at the improvement the treatment made to their everyday lives.

An article on the study was published online by European Urology and is freely available.


This article originally appeared on TheDoctorWillSeeYouNow.com, an Atlantic partner site.

Presented by

How to Cook Spaghetti Squash (and Why)

Cooking for yourself is one of the surest ways to eat well. Bestselling author Mark Bittman teaches James Hamblin the recipe that everyone is Googling.

Join the Discussion

After you comment, click Post. If you’re not already logged in you will be asked to log in or register.

blog comments powered by Disqus

Video

How to Cook Spaghetti Squash (and Why)

Cooking for yourself is one of the surest ways to eat well.

Video

Before Tinder, a Tree

Looking for your soulmate? Write a letter to the "Bridegroom's Oak" in Germany.

Video

The Health Benefits of Going Outside

People spend too much time indoors. One solution: ecotherapy.

Video

Where High Tech Meets the 1950s

Why did Green Bank, West Virginia, ban wireless signals? For science.

Video

Yes, Quidditch Is Real

How J.K. Rowling's magical sport spread from Hogwarts to college campuses

Video

Would You Live in a Treehouse?

A treehouse can be an ideal office space, vacation rental, and way of reconnecting with your youth.

More in Health

Just In