Beyond Lipitor: New Injections Could Help Reduce 'Bad' Cholesterol

The 'bad' kind of cholesterol, 'LDL,' has been effectively targeted by drugs like Lipitor known as statins. A treatment now in clinical trials could do even better.

The Doctor Will See You Now
Wallenrock/Shutterstock

For people whose cholesterol is resistant to medication or for those who cannot tolerate statins, a new type of therapy may bring some relief. The treatment uses antibodies to help increase the number of LDL receptors in liver cells, so that more of the "bad" cholesterol molecules can be cleared from the bloodstream. The reason that LDL is known as the "bad" form is that it can aggregate in the blood vessels, forming the plaques that restrict blood flow and put one at greater risk for heart attack.

A while ago it was discovered that statin drugs increased the amount of a particular enzyme, PCSK9, which destroys LDL receptors. So researchers developed a monoclonal antibody known as SAR236553/REGN727, which binds to the enzyme PCSK9. This binding essentially allows more LDL receptors to stick around, which helps rid the body of more LDL cholesterol.

More research will be required to learn more about dosing and safety before they hit the market. Still, to get such a strong effect after giving statins is promising.

In this experiment, the research team randomly assigned people who had been treated with Lipitor for six weeks to one of six groups. The study was a phase 2 clinical trial, meaning that the researchers were trying to find the most effective dose and frequency for administering the drug. Therefore, three groups were injected with the new antibody in high, medium, or low doses (50, 100, or 150 mg) every two weeks. Two more groups had higher doses (200 or 300 mg, respectively) four weeks apart. The remaining group was given placebo.

The results were striking: the patients who got the low, medium, and high doses every two weeks had reductions of their LDL cholesterol by 40 percent, 64 percent, and 72 percent, respectively. The people who got the two higher doses had reductions of 43 percent and 48 percent. The placebo group saw reductions of their cholesterol by only five percent.

Another study published this week found similar results for the treatment in people with genetic predispositions to having very high cholesterol and those without this family trait. But this study was a phase 1 trial, and was more interested in safety issues than nailing down the dosing and timing of the drug. Side effects were few, and no patients in the study discontinued the treatment because of adverse effects.

Further research will be required to learn more about dosing and safety before they hit the market. Still, to get such a strong effect after giving statins is promising. "Statins are good medicines and getting a 70 percent reduction on top of them is remarkable," said lead author James McKenney in a news release. "This is a very hopeful step in the treatment of heart disease in this country."

McKenney is CEO of National Clinical Research Inc. The study was presented at the American College of Cardiology's annual meeting and published in the Journal of the American College of Cardiology.


This article originally appeared on TheDoctorWillSeeYouNow.com, an Atlantic partner site.

Presented by

Alice G. Walton, PhD, is a health journalist and an editor at The Doctor Will See You Now.

How to Cook Spaghetti Squash (and Why)

Cooking for yourself is one of the surest ways to eat well. Bestselling author Mark Bittman teaches James Hamblin the recipe that everyone is Googling.

Join the Discussion

After you comment, click Post. If you’re not already logged in you will be asked to log in or register.

blog comments powered by Disqus

Video

How to Cook Spaghetti Squash (and Why)

Cooking for yourself is one of the surest ways to eat well.

Video

Before Tinder, a Tree

Looking for your soulmate? Write a letter to the "Bridegroom's Oak" in Germany.

Video

The Health Benefits of Going Outside

People spend too much time indoors. One solution: ecotherapy.

Video

Where High Tech Meets the 1950s

Why did Green Bank, West Virginia, ban wireless signals? For science.

Video

Yes, Quidditch Is Real

How J.K. Rowling's magical sport spread from Hogwarts to college campuses

Video

Would You Live in a Treehouse?

A treehouse can be an ideal office space, vacation rental, and way of reconnecting with your youth.

More in Health

Just In