The FDA Did Not Do Enough to Restrict Antibiotics Use in Animals

Despite big talk, the agency did not confront the structural problem of antibiotic use in farm animals, which means the public health dangers of meat production remain.



"FDA takes steps to protect public health," blared the Food and Drug Administration (FDA) press release announcing the release of voluntary guidance documents on Wednesday. The documents outline how antibiotics should--and should not--be used in food animal production to slow the development of antibiotic-resistant bacteria. The agency has trumpeted the documents as the beginning of the end of the misuse of these drugs on farms.

The FDA missed the point, however. While the documents call for ending the use of antibiotics to make animals grow faster, they endorse the continued use of these drugs to compensate for overcrowded and unsanitary conditions and prevent disease at the industrial operations that produce most food animals in this country. The preventive or "prophylactic" use of antibiotics is similar to their use for growth promotion, involving comparable low doses that are equally culpable in the development of antibiotic resistance.

The FDA calls preventive use "necessary to assure animal health." Left unaddressed is what makes this use "necessary." The industrial model of food animal production increases animals' exposure to bacterial pathogens and weakens the animals' immune system through overcrowding and the suppression of normal animal behaviors, leaving them susceptible to infections without the continuous administration of low doses of antibiotics. Rather than ban preventive use of antibiotics to require the industry to raise animals in a manner that assures both public and animal health, the guidance document accommodates an industry that undermines both.

The Low-Hanging Fruit

The guidance documents spell out two principles for the "judicious use" of antibiotics in food animal production. First, antibiotics should only be used when "necessary to assure animal health." This means the treatment, control, and prevention of disease, but not growth promotion, according to the FDA. Second, antibiotics should be available only when prescribed by a veterinarian and not sold over the counter.

The misuse of antibiotics by the food animal industry is not just a means to make a quick buck; misusing these drugs is the lynchpin of the industrial model.

The FDA had previously approved the use of several antibiotics for growth promotion. Rather than forcibly withdraw these approvals--a move that many drug companies would oppose--the agency believes it can persuade drug companies to voluntarily change existing approvals to comply with the guidance documents. The Animal Health Institute, an industry lobby group, has said it supports the guidances, as have several pharmaceutical executives.

We can expect the FDA and drug companies to revoke existing approvals for growth promotion over the next several years. Likewise, the agency and the drug industry will gradually end the sale of antibiotics over the counter.

The effect of these actions on the use of antibiotics will depend in part on whether or not the food animal industry complies with the changes. There is good reason to doubt the food animal industry will comply. A recent study by the Johns Hopkins Center for a Livable Future, which I direct, strongly suggests that the poultry industry has continued to use a class of antibiotics known as fluoroquinolones, despite an FDA ban on the use of these drugs in chickens and turkeys. These findings raise an important question: how can we expect the industry to comply with voluntary guidance documents if it does not follow existing law?

Even if the food animal industry complies, however, the misuse of antibiotics will continue, because the guidance documents endorse the use of these drugs for disease prevention. Like growth promotion, this means feeding small quantities of antibiotics to food animals throughout their lives--a practice that has been shown time and again to select for antibiotic resistance. It is quite different from the preventive use of antibiotics in human medicine, which is relatively rare and involves the use of full doses for short durations.

Although growth promotion may be phased out, the drug and food animal industries will not give up the use of antibiotics for disease prevention so easily, as preventive use of these drugs is essential to the industrial model of food animal production.

The Industrial Model

The second half of the twentieth century witnessed the transformation of animal agriculture. Beginning in the 1940s, small independent farms were subsumed by industrial operations controlled by a small handful of large corporations. Since the 1950s, the number of food animals produced in the United States has doubled, while the number of production sites has declined by 80 percent. This efficiency is unprecedented, but the methods used to achieve it have left animals exceedingly vulnerable to bacterial infection and disease.

Presented by

Dr. Robert S. Lawrence is professor of Environmental Health Sciences, Health Policy, and International Health at the Johns Hopkins Bloomberg School of Public Health, and founding director of the Center for a Livable Future.

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