Stress Makes You Sick: Exploring the Immune System Connection


Science has yet to map all of the mechanisms behind the stress-immunity connection, but a new study proves the danger of inflammation.

Margarita Borodina/Shutterstock

Conventional wisdom tells us that stress can make us sick. This seems likely enough, though science hasn't exactly mapped all the mechanisms that would explain the connection. Now a new study highlights which immune system compounds could be to blame, making it clear that reducing stress could enhance immunity.

A group of 122 participants filled out questionnaires about their activities over a period of eight days, noting whether their interactions with others were positive or negative. They also took stressful tests in the lab, before and after which their saliva was tested to measure markers of inflammation called cytokines.

The participants' levels of cytokines, like interleukin-6 (ILK-6), rose after stressful negative events, often arguments or competitive social interactions. They were not elevated after competitive sports games, suggesting that sports may involve a friendlier form of competition, while competitive social interactions are experienced as negative events.

"The message is that the flotsam and jetsam of life predict changes in your underlying biology in ways that cumulatively could have a bad effect on health," said study author Shelley Taylor. "What this tells me is that people should be investing in socially supportive relationships, and they should not court relationships that lead to a great deal of conflict."

Higher levels of inflammatory markers can, over time, lead to all kinds of problems, from heart disease to cancer. "If you aren't wounded, there's no place for them to go, and they're circulating," Taylor said. "It's not like they've gone to the site of a wound and engaged in anti-infection activity."

One remaining question is whether stress causes inflammation, or whether there is a more nuanced relationship. People who are more stressed-out by nature could develop more inflammation as a result, or it may be that people with more inflammation to begin with could feel more stressed (and have more negative social interactions) in turn.

More research will be needed to understand this fundamental relationship between stress and immunity. While this is being done (and it will no doubt take a few years or decades before we understand it all), de-stressing as much as possible, doing what you can to reduce feelings of stress, is clearly helpful. Exercise, yoga, meditation, and talk therapy are all effective ways to lessen your mental load and calm your body's systems.

The study was carried out by a team at the University of California, Los Angeles, and published in the Proceedings of the National Academy of Sciences.

This article originally appeared on, an Atlantic partner site.

Jump to comments
Presented by

Alice G. Walton, PhD, is a health journalist and an editor at The Doctor Will See You Now.

Get Today's Top Stories in Your Inbox (preview)

What's the Number One Thing We Could Do to Improve City Life?

A group of journalists, professors, and non-profit leaders predict the future of livable, walkable cities

Elsewhere on the web

Join the Discussion

After you comment, click Post. If you’re not already logged in you will be asked to log in or register. blog comments powered by Disqus


Adventures in Legal Weed

Colorado is now well into its first year as the first state to legalize recreational marijuana. How's it going? James Hamblin visits Aspen.


What Makes a Story Great?

The storytellers behind House of CardsandThis American Life reflect on the creative process.


Tracing Sriracha's Origin to Thailand

Ever wonder how the wildly popular hot sauce got its name? It all started in Si Racha.


Where Confiscated Wildlife Ends Up

A government facility outside of Denver houses more than a million products of the illegal wildlife trade, from tigers and bears to bald eagles.


Is Wine Healthy?

James Hamblin prepares to impress his date with knowledge about the health benefits of wine.


The World's Largest Balloon Festival

Nine days, more than 700 balloons, and a whole lot of hot air



More in Health

Just In