Treatments for Mad Cow, Other Prion Diseases May Be Coming

More

Researchers at NYU have made a key step in developing a treatment for Creutzfeldt-Jakob and a host of other brain-wasting diseases

MadCow-Reuters-Post.jpg

There are currently no treatments for prion diseases, brain-wasting diseases that are invariably fatal. The most common human prion disease is Creutzfeldt-Jakob disease (CJD), better known as mad cow disease.

Researchers at NYU School of Medicine recently took a key step in developing an effective treatment. They found four compounds that significantly delayed disease onset in mice. Because prion diseases are extremely slow to develop, any treatment that delays their initial symptoms long enough could potentially be life saving. And two of these anti-prion compounds are drugs already used to treat other conditions in humans, meaning that clinical trials of them may soon be underway.

The two drugs are trimipramine, an antidepressant, and fluphenazine, an antipsychotic.

Prion diseases destroy brain tissue. Collectively they're known as spongiform encephalopathies because the holes in a disease-riddled brain give it a sponge-like appearance. Animal diseases include bovine spongiform encephalopathy (BSE), commonly known as mad cow disease, scrapie and chronic wasting disease. BSE can be transmitted to humans -- over 200 people are known to have died from it, presumably from eating contaminated meat.

Prions are misfolded proteins that can produce infection and disease by eventually causing normal proteins to also misfold. Over time, once enough misfolded proteins accumulate, brain degeneration occurs. The incubation time (from infection to disease symptom appearance) is very long, anywhere from several months to decades.

While little is currently known about treating prion diseases, they may ultimately prove simpler to treat than bacterial infections. To cure a bacterial infection, all the bacteria must be killed. To effectively treat a prion disease, it may be enough to simply slow down the rate of prion growth, turning what's already a long process into a longer one that will not produce disease in a person's lifetime. The current study results are a step in that direction.

The researchers tested 68 related compounds known as styryl-based compounds, as well as trimipramine and fluphenazine, for their ability to prevent prion infections in mouse cell cultures and for toxicity. Both drugs and two of the styryl compounds, numbers 231 and 59, showed good effectiveness and were non-toxic. The researchers then tested these four compounds in mice that had been experimentally infected with prions.

Infected mice treated with any of the four compounds took 20-25 percent longer before displaying disease symptoms, with compound 231 giving the best results. And one mouse treated with trimipramine survived for the entire 400-day study, showing no disease symptoms or prion accumulation in the brain.

For ethical reasons, any mice showing disease symptoms were sacrificed three weeks after the symptoms first appeared. So the study couldn't tell much about how the four compounds slowed disease progression, only that they were somewhat effective at delaying the onset of disease symptoms. Autopsy did show that the brain tissue of treated mice had less degeneration than those of the untreated mice, presumably meaning that these compounds did slow disease progression.

The researchers hope that tests of trimipramine and fluphenazine in people with CJD will begin soon.

An article on the study was published by PLoS ONE and is freely available. To see it, click here.

Image: REUTERS/Lee Jae Won.


This article originally appeared on TheDoctorWillSeeYouNow.com.

Jump to comments
Presented by
Get Today's Top Stories in Your Inbox (preview)

A Wild Vacation in the Pacific Northwest

A not-so-ordinary road trip, featuring extra-tall art bikes, skateboards, and hand-painted vans


Elsewhere on the web

Join the Discussion

After you comment, click Post. If you’re not already logged in you will be asked to log in or register. blog comments powered by Disqus

Video

Adventures in Legal Weed

Colorado is now well into its first year as the first state to legalize recreational marijuana. How's it going? James Hamblin visits Aspen.

Video

What Makes a Story Great?

The storytellers behind House of CardsandThis American Life reflect on the creative process.

Video

Tracing Sriracha's Origin to Thailand

Ever wonder how the wildly popular hot sauce got its name? It all started in Si Racha.

Video

Where Confiscated Wildlife Ends Up

A government facility outside of Denver houses more than a million products of the illegal wildlife trade, from tigers and bears to bald eagles.

Video

Is Wine Healthy?

James Hamblin prepares to impress his date with knowledge about the health benefits of wine.

Video

The World's Largest Balloon Festival

Nine days, more than 700 balloons, and a whole lot of hot air

Writers

Up
Down

More in Health

Just In